A Randomised Open Clinical Study on the Efficacy of ‘Sumukti’- an Indigenous Compound on Subjective Symptoms of Madatyaya With Special Reference to Alcohol Dependence

Authors

  • Unnikrishnan PM Clinical Consultant, Department of Manasaroga, Sri Sri College of Ayurvedic Science & Research Hospital, Bangalore, Karnataka. https://orcid.org/0000-0002-9034-0871
  • Savitha HP Associate Professor, Department of Manasaroga, SDM College of Ayurveda, Hassan, Karnataka.
  • Suhas K Shetty Professor and Head of Department, Department of Manasaroga, SDM College of Ayurveda, Hassan, Karnataka.
  • Narayana Prakash B Professor, Department of Kayachikitsa, Dr. Vijay’s Ayurvedic Medical College, Varanasi, U.P.
  • Pooja G Hassan Diet Consultant and Yoga Instructor, Sri Sri College of Ayurvedic Science & Research Hospital, Bangalore, Karnataka.

Keywords:

Madatyaya, Alcohol Dependence, Sumukti

Abstract

Introduction: With more than half of all alcohol drinkers in India falling into criteria for hazardous drinking, alcohol related disorders are emerging as a major public problem in country. In Ayurveda alcohol related disorders are correlated to Madatyaya. Here we observe the vitiation of Shareerika and Manasika Doshas and the treatment consists of Doshavasechana, Rasayana and Satvavajaya chikitsa. To fulfill all these treatment measures, an indigenous compound named ‘Sumukti’ which contains 11 drugs with multiple properties of Dosha shamana, Rasayana, Medhya and Yakrit Uttejaka was prepared and administered in the patients of Madatyaya WSR to alcohol dependence.

Aims & Objectives: To study the efficacy of indigenous compound- ‘Sumukti’ on alcohol dependence.

Methodology: 52 patients were screened by using ‘Alcohol Dependence Scale’. 30 patients who fulfilled the inclusion criteria of Madatyaya WSR to alcohol dependence from OPD and IPD of SDM College of Ayurveda and Hospital, Hassan were selected and compound ‘Sumukti’ was given in the dose of 15ml, thrice a day before half an hour of food for 30 days.

Result: There was statistically significant effect seen in subjective parameters with more than 60% improvement. Moderate improvement (50-74%) was seen in majority of patients (53.33%). Marked improvement (75-99%) also seen in 43.33% of patients (13).

Conclusion: Compound found effective in subjective symptoms and can be a choice of medicine in alcohol dependence.

References

Kaplan and Sadock. Comprehensive text book of psychiatry. Sadock BJ, Sadock VA, ed., 8th edition.

Lippincott Williams and Wilkins, USA. 2005. Vol I. 1169.

Murthy P, Manjunatha N, Subodh BN, Chand PK, Benegal V et al. Substance use and addiction research in India. IJPsy 2010; 52(7): 189-199. Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;yea

r=2010;volume=52;issue=7;spage=189;epage=199;aulast=Murthy [PubMed/ Google Scholar].

Prasad R. Alcohol use on the rise in India. 2009. pp.17-18. Available from: http://www.thelancet.com/

journals/lancet/article/PIIS0140-6736(08)61939-X/fulltext.

Kaplan and Sadock. Comprehensive text book of psychiatry. Sadock BJ, Sadock VA, ed., 8th edition.

Lippincott Williams and Wilkins, USA. 2005. Vol I. 1139.

Charaka A, Chakrapanidatta D. In: Acharya JT (eds.) Charaka Samhita with Ayurveda Deepika commentary.

Reprint 2009 ed. Chaukhamba Prakashan, Varanasi. 2009, 584.

Charaka A, Chakrapanidatta D. In: Acharya JT (eds.) Charaka Samhita with Ayurveda Deepika commentary.

Reprint 2009 ed. Chaukhamba Prakashan, Varanasi. 2009, 587.

The Ayurvedic Pharmacopoeia of India. National institute of Science Communication and Information

Resources [NISCAIR], CSIR, New Delhi. 2006. Part I; Vol I. 41-42. Available from: ayurveda.hu/api/API-Vol-1.pdf

The Ayurvedic Pharmacopoeia of India. National institute of Science Communication and Information

Resources [NISCAIR], CSIR, New Delhi. 2006. Part I; Vol I. 47-48. Available from: http://www.ayurveda.

hu/api/API-Vol-1.pdf.

The Ayurvedic Pharmacopoeia of India. National institute of Science Communication and Information

Resources [NISCAIR], CSIR, New Delhi. 2006. Part I; Vol I. 15-16. Available from: http://www.ayurveda.

hu/api/API-Vol-1.pdf.

The Ayurvedic Pharmacopoeia of India. National institute of Science Communication and Information

Resources [NISCAIR], CSIR, New Delhi. 2006. Part I; Vol III. 45-46. Available from: http://www.ayurveda.

hu/api/API-Vol-1.pdf.

The Ayurvedic Pharmacopoeia of India. National institute of Science Communication and Information

Resources [NISCAIR], CSIR, New Delhi. 2006. Part I; Vol I. 127-128. Available from: http://www.ayurveda.hu/

api/API-Vol-1.pdf.

Charaka A, Chakrapanidatta D. In: Acharya JT (eds.) Charaka Samhita with Ayurveda Deepika commentary.

Reprint 2009 ed. Chaukhamba Prakashan, Varanasi. 2009, 491.

Kaplan and Sadock. Comprehensive text book of psychiatry. Sadock BJ, Sadock VA, ed., 8th edition.

Lippincott Williams and Wilkins, USA. 2005. Vol I. 1172.

Kaplan and Sadock. Comprehensive text book of psychiatry. Sadock BJ, Sadock VA, ed., 8th edition.

Lippincott Williams and Wilkins, USA. 2005. Vol I. 1173.

Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties

of Tinospora cordifolia in CCl4 intoxicated mature albino rats. The Journal of Toxicological Sciences 2002; 27(3):

-146. [PubMed/ Google Scholar/ ResearchGate].

Aher V, Wahi A. Immunomodulatory Activity of Alcohol Extract of Terminalia chebula Retz Combretaceae.

Tropical Journal of Pharmaceutical Research 2011; 10(5): 15670. Available from: https://www.ajol.info/

index.php/tjpr/article/view/71665 [Google Scholar].

Reddy VD, Padmavathi P, Paramahamsa M, Varadacharyulu NC. Amelioration of alcohol-induced

oxidative stress by Emblica officinalis (amla) in rats. Indian J Biochem Biophys 2010; 47(1): 20-25. [PubMed/

Google Scholar].

Pari L, Suresh A. Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats.

Food and Chemical Toxicology 2008; 46(5): 1627-1634. [PubMed/ Google Scholar/ ResearchGate].

The Ayurvedic Pharmacopoeia of India. National institute of Science Communication and Information

Resources [NISCAIR], CSIR, New Delhi. 2006. Part I; Vol II. 21-24. Available from: http://www.ayurveda.

hu/api/API-Vol-1.pdf.

Balasundari P, Singh SK, Kavimani S. Free radical scavenging of xanthones from SwertiachirataBuchham and tumor cell growth inhibition. Main Group Chemistry 2005; 4(3): 177-185.

Available from: https://www.tandfonline.com/doi/abs/10.1080/10241220500324209 [Google Scholar].

Young-Won C, Hyun-Ah J, Yue L, et al. Anti-oxidant constituents of the roots and stolons of Licorice

(Glycyrrhiza glabra). Journal of Agric Food Chem 2007; 55(12): 4691-4697. Available from: https://pubs.acs.

org/doi/abs/10.1021/jf0703553 [PubMed/ Google Scholar/ ResearchGate].

Charaka A, Chakrapanidatta D. In: Acharya JT (eds.) Charaka Samhita with Ayurveda Deepika commentary.

Reprint 2009 ed., Chaukhamba Prakashan, Varanasi. 2009, 585.

Charaka A, Chakrapanidatta D. In: Acharya JT (eds.) Charaka Samhita with Ayurveda Deepika commentary.

Reprint 2009 ed., Chaukhamba Prakashan, Varanasi. 2009, 586.

Mathew M, Sarada S. Evaluation of the antiamyloidogenic potential of nootropic herbal extracts in

vitro. International Journal of Pharmaceutical Sciences & Research 2012; 3(11): 4276-4280. Available from:

http://ijpsr.com/bft-article/evaluation-of-the-antiamyloidogenic-potential-of-nootropic-herbal-extractsin-

vitro/?view=fulltext [Google Scholar].

Reena K, Girish KJ, Abhimanyu K. Nootropic herbs (Medhya Rasayana) in Ayurveda: An update.

Pharmacogn Rev. 2012; 6(12): 147-153. [PubMed/ Google Scholar/ ResearchGate].

Krishnamurthy RG, Marie-Claude S, Daniel Z, Jiangyong M, Mark BF, Eric JG et al. Asiatic acid, a pentacyclic

triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. Journal

of Neuroscience Research 2009; 87(11): 2541-2550. [PubMed/ Google Scholar].

Downloads

Published

2019-11-28