Etiology, Symptoms, Neuropathology and Management of Alzheimer’s Disease: A Neurodegenerative Disorder


  • Vishal Kumar Vishwakarma Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
  • Shravan Kumar Paswan Pharma Talk Research Foundation, Lucknow, Uttar Pradesh, India.
  • Nishi Shukla Department of Pharmacognosy, Babu Banarasi Das Northern India Institute of Technology, Lucknow, Uttar Pradesh, India.
  • Shivjee Kashyap Department of Pharmaceutical Chemistry, KJ College of Pharmacy, Varanasi, Uttar Pradesh, India.
  • Pritt Verma Pharma Talk Research Foundation, Lucknow, Uttar Pradesh, India.


Alzheimer’s disease (AD) is a neurological disorder reflected by memory loss and affecting daily living activities. The pathological alterations of Alzheimer’s disease are mainly through neuritic plaques which are the accumulation of beta-amyloid protein and also neurofibrillary tangles. This review has been accomplished on various pathological alterations, causes, treatment and management of Alzheimer’s disease targeting towards cholinergic deficiency, inflammation and oxidative stress. The management and therapy of Alzheimer’s disease include Memantine, cholinesterase inhibitors, ACE inhibitors, secretase inhibitors and anti-
inflammatory drugs including various vitamins, minerals and herbal drugs. This review aims to focus on the mechanism of oxidative stress including its role in the progression of the disease.

How to cite this article: Vishwakarma VK, Paswan SK, Shukla N et al. Etiology, Symptoms, Neuropathology and Management of Alzheimer’s Disease: A Neurodegenerative Disorder. Int J Adv Res Pharm Edu 2020; 2(1): 16-23.


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