Anti-Gram-Positive and Anti-GramNegative Pathogen Killing Potentials of 3-[((4-(1,3-dioxoisoindolin-2-yl)phenyl)hydroxyl) methylene amino]-4-Methyl Benzoic Acid
Abstract
Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, phthalimide-based compounds were identified and their Schiff’s base-based hybridized molecules were designed. In one of the recent rational exploration, 3-[((4-(1,3-dioxoisoindolin-2-yl)phenyl) hydroxyl)methylene-amino]-4-methyl benzoic acid was synthesized in a two-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, Mass spectroscopy, and 1 H-NMR spectroscopy, as well as CHN Analyzer, and ultimately screened for its anti-bacterial potentials against gram negative microbial species (Escherichia coli) and gram-positive microbial species (Staphylococcus aureus) using the conventional procedure. The chemical structure of the proposed molecule was completely recognized by sophisticated spectroscopic instruments. The compound exhibited an incredible anti-bacterial activity against anti-E. coli and expressed a fair bacterial activity against anti-S. aureus in in-vitro anti-microbial screening model, but with a very low potency. The compound was found to be more effective towards Gram-negative species. The investigation pointed towards several prospective for the development of broadspectrum anti-microbial drugs against resistant pathogenic strains by looking insights into the unexplored class of phthalimide-based hybrid Schiff’s base compound.
How to cite this article: Dhabarde DM, Shambharkar P, Kamble MA et al. Anti-Gram-Positive and Anti-Gram-Negative Pathogen Killing Potentials of 3-[((4-(1,3-dioxoisoindolin-2-yl)phenyl)hydroxyl)methylene amino]-4-Methyl Benzoic Acid. Int J Adv Res Pharm Edu 2020; 2(1): 2-5.
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