Uses of Diazo Dyes as Drugs
Abstract
Dyes were used for dying textiles and other materials and in biology, these were used for identifying various types of pathogens like bacteria, protozoa, etc. Paul Ehrlich was working on biological properties of these dyes on blood cells, demonstrating the specific staining of parts of certain leucocytes, the basis of hematology. In order to test the hypothesis that it is possible to stain pathogens specifically and perhaps be killed without harming the host, Ehrlich’s laboratory focused first on malaria protozoa using methylene blue and related dyes. For five years, Ehrlich and his associates studied hundreds of synthesized dyes leading to the first synthetic antimalarial, Tryphan red in 1904.
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