Short Notes on Diaryl Ureas Derivatives

Authors

  • Mohammad Asif Department of Pharmacy, GRD(PG) Institute of Management & Technology, 248009, Dehradun, (Uttarakhand), India

Abstract

Ureas are a very important class of compounds due to their extensive application as agrochemicals, dyes for cellulose fibers, antioxidants in gasoline, hair dyes, additives in hydrocarbon fuels, detergents, and polymers, corrosion inhibitors and as synthetic intermediates.1 Disubstituted ureas not only possess industrial application, their biological potency is also widely exploited. Substituted ureas have been of recent interest due to potent biological activities like HIV protease inhibitors,2,3 FKBP12 inhibitors4,5 and semicarbazides as CCK-B receptor antagonists6 and endothelin antagonist.

References

1. Abd El-Nabi HA, El-Din AMN, Fahmi MS. J. Chem. Res. Synop 2003; 3: 514.
2. Lam PYS, Jadhav PK, Eyermann CJ et al. Science 1994; 263: 380.
3. Lam PYS, Ru Y, Jadhav PK et al. J. Med. Chem 1996; 39: 3514.
4. Dragovich PS, Barker JE, French J et al J. Med. Chem 1996; 39:1-12.
5. Semple G, Ryder H, Rooker DP et al. J. Med. Chem 1997; 40: 331.
6. Castro JL, Ball RG, Broughton HB et al. J. Med. Chem 1996; 39: 842.
7. Vongeldem TV, Kester JA, Bal R et al. J. Med Chem 1996; 39: 968.
8. Shaoyong Ke, Zhong Lif, Xuhong Qian. Bioorg. Med. Chem. Lett 2008; 16: 7565.
9. Ogletree ML, Natajaran S, Seller S et al. Perspect, Drug Discovery Des 1994; 1: 527.
10. Coughlin SR. Thromb. Haemostasis 1993; 70: 184.
11. (a) McNamara CA, Sarmbock IJ, Gimple L et al. Clin. Invest 1993; 9: 94. (b) Coughlin SRJ. Thromb. Haemostasis 2005; 3: 1800.
12. Zania P, Kritikou S, Flordellis CS et al. J. Pharmacol. Exp. Ther 2006; 318: 246.
13. Zhang HC, McComsey DF, White KB et al. Bioorg. MedChem. Lett 2001; 11: 2105.
14. Severino B, Fiorino F, Perissutti E et al. Bioorg. MedChem. Lett 2008; 16: 6009.
15. Kerwin Jr JF. Drugs Future 1991; 16: 1111.
16. Hagishita S, Murakami Y, Seno K et al. Bioorg. Med. Chem 1997; 5: 1695.
17. Yednock TA, Cannon C, Fritz LC et al. Nature 1992; 356: 63.
18. Piraino PS, Yednock TA, Freedman SB et al. J. Neuroimmunol 2002; 131: 14.
19. Mure F, Limura S, Yoneda Y et al. Bioorg. Med. Chem. Lett 2008; 16: 9991.
20. Kozurkova M, Sabolova D, Janovec L et al. Bioorg. MedChem. Lett 2008; 16: 3976.
21. Gaudreault RC, Lacroix J, Pag M et al. J. Pharm. Sci 1988; 77: 185.
22. Gaudreault RC, Alaoui-Jamali MA, Batist G et al. Cancer Chemother. Pharmacol 1994; 33: 489.
23. Jessica Fortin S, Marie-France Cote, Lacroix J et al. Bioorg. Med. Chem. Lett 2008; 16: 7277.
24. Lam PYS, Jadhav PK, Eyermann CJ et al. Science 1994; 263: 380.
25. Lam PYS, Ru Y, Jadhav PK et al. J. Med. Chem 1996; 39: 3514.
26. Dragovich PS, Barker JE, French J et al. J. Med. Chem1996; 39: 1872.
27. Semple G, Ryder H, Rooker DP et al. J. Med. Chem 1997; 40: 33L.
28. Vishnyakova TP, Golubeva IA, Glebova RV. Russ. Chem. Rev. (Engl. Transl.) 1995; 54: 249.
29. Stone BRP, Harris GD, Cann RO et al. Tetrahedron Let 1998; 39: 6127.
30. Dumas J, Hatoum-Mokdad H, Sibley R et al. Bioorg. Med. Chem. Lett 2000; 10: 2051.
31. Petersen U. Methoden der Organischen Chemie; Houben- Weyl, E4; G. Thieme Verlag: New York. 1983;
334.
32. Petersen U. In Methoden der Organischen Chemie; Houben- Weyl, E4; G. Thieme Verlag: New York. 1983;
334.
33. Vishnyakova TP, Golubeva LA, Glebova EV. Russ. Chem. Rev. (Engl. Transl.) 1985; 13: 249.
34. Nowick JS, Powell NA, Nguyen TM et al. J. Org. Chem 1992; 57: 7364.
35. Yang G, Chen ZX, Zhang HQ. Green Chem 2003; 5: 441.
36. Colquhoun HM, Thompson DJ, Twigg MV. Reaction mechanisms. New York: Plenum 1991.
37. Sheldon RA. Boston: Dordrecht 1983; 34: 213.
38. Wender I, Pino P. Catalysts - Principles and Applications. New York: Wiley-Interscience 1968; 1: 126.
39. Sawai H, Takizawa T. Tetrahedron Lett 1972; 42: 4263.
40. Schreiber J, Witkop BJ. J. Am. Chem. Soc 1964; 86: 2441.
41. Kehm BB, Whitehead CW. Org. Synth. Coll 1963; IV: 515.
42. Olszewski TJ. Tetrahedron Lett 1998; 39: 1107.
43. Cacchi Y, Misiti D, F La Tore. Synthesis 1980; 13: 243.
44. Patil VM, Sangapure SS, Agasimundin YS. Indian J. Chem 1984; 238: 132.

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Published

2018-09-07

Issue

Vol. 1 No. 1&2 (2018): Journal of Advanced Research in BioChemistry and Pharmacology

Section

Research Article

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