Abstract
Breast cancer is recognized as a commonly occurring cancer in women wherein the cancerous growth occurs in the breasts. The current treatment strategies face a significant setback due to the development of resistance against the subjected drug, i.e., after a few treatment cycles, the drug efflux increases as the body becomes resistant to the therapeutics, thereby taking a toll on the effectiveness of the treatment. Although various pathways are involved in tumorigenesis, studies revolve across a signaling pathway referred to as the Wnt signaling pathway. The Wnt pathway is responsible for regulating cell proliferation and apoptosis. Activation of the Wnt pathway results in cancer-like conditions. A detailed understanding of the Wnt pathway would help researchers break the concept of drug resistance and develop effective treatment strategies. In this review, the authors will talk about the Wnt Signaling Pathway, its role in breast cancer, the resistance against the therapeutics due to dysregulated Wnt pathway, and the current advancements.
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