Adverse Drug Reactions of Anti-Cancer Drugs and its Management: A Review
Keywords:
Cytotoxicity, Anticancer drugs, Toxicity, Management of side effects, Antineoplastic agentsAbstract
For safe use of medicines, awareness regarding the existing knowledge of Adverse Drug Reactions (ADRs) is essential to prevent, identify, and manage them. One of the characteristics of anticancer agents has the frequency and severity of side effects at therapeutic doses. Most cytotoxic drugs targets on rapidly multiplying cells and their targets are the nucleic acids, which are rapidly synthesised during cell division. Many solid tumours have a lower growth fraction than the normal bone marrow, gastro intestinal lining, reticuloendothelial system and gonads. Drugs affect these tissues in a dose dependant manner and there is individual susceptibility also. So, toxicities are more frequently associated with these tissues. The side effects may be acute or chronic, self-limited, permanent, mild or potentially life threatening. Management of these side effects is of utmost importance because they affect the treatment, tolerability and overall quality of life. This paper gives an overview of different toxicities of anticancer drugs and its management. Knowledge of assessment of ADR due to different antipsychotics is necessary. It helps to choose to safe treatment and reduce the risk of occurrence of ADRs by the clinicians.
Occurrence of ADR had largely affected hospital stay of patients indirectly influencing economic burden on patients. ADR are often poorly identified and reported in day to day medical practice. As we collect more and more information about ADRs, we need an active surveillance system regarding identification and reporting of ADRs with anticancer drugs.
How to cite this article: Srivastava N, Majumder A, Rastogi S. Adverse Drug Reactions of Anti-Cancer Drugs and its Management: A Review. Int J Adv Res Med Chem 2019; 1(1): 19-27.
References
Srinivasan R, Ramya G. Adverse drug reaction-causality assessment. Int J Res Pharm Chem 2011; 1: 606–12.
Devita VT, Hellman S, Rosenberg SA. Principles and Practise of Oncology, 6th edition, Lippincott Williams and Wilkins 2256-315.
Rang HP, Dale MM, Ritter JM. Anticancer drugs, Text book of Pharmacology, Elsevier; 2012; 7th edition: 673-87.
Brenner GM, Stevens CW. Antineoplastic drugs, Text book of Pharmacology, Saunders Elsevier. 2010; 493511.
Gupta S, Tannous R, Friedman M. Incidence of anaemia in CHOP-treated intermediate-grade non-Hodgkin’s lymphoma (IGNHL). Euro J Cancer 2001; S94:339.
Hoagland HC, Gastineau DA. Haematological complications of cancer chemotherapy, The chemotherapy source book, Michael C Perry. 1992; 559.
American Society of clinical Oncology recommendations for the use of Hematopoietic CSF, Evidence based clinical practise guidelines. J Clin Oncol 1994; 12: 2471508.
Berg SL, Balis FM. David G Pop lack: Cancer Chemotherapy: Haematology of infancy and childhood, Nathan and Oski’s, 1998; 1218.
Furie B, Cassileth PA, Atkins MB et al. Clinical haematology and oncology: presentation, diagnosis, and treatment: Chapter 66, (First Edition) Churchill Livingstone, Philadelphia, 2003; 636-647.
Doordujin JK, van der Holt B, van Imhoff GW et al. CHOP compared with CHOP plus granulocyte stimulating factor in elderly patients with aggressive non-Hodgkin’s Lymphoma. J Clin Oncol 2003; 21: 3041-3050.
Pizzo PA, Schimpff. Strategies for the prevention of infection in myleo suppressed cancer patients. Cancer Treat Rev 1983; 67: 223-234.
Hughes WT. Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002; 34: 730-751.
Schiffer CA, Anderson KC, Benet. Platelet transfusion for patients with cancer; Clinical practise guidelines of the American Society, Clinical oncology. J ClinOncol 2001; 19: 1519-38.
Rittenberg CN. New class of antiemetic agents on horizon. Clin J OncolNurs 2002; 6:103-4.
Douglas Peterson, NC Shubert. Cancer chemotherapy source book, Michel C Perrie; 2001; 3:406-24.
Sharma R., Tobin P and Clarke SJ. Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea. Lancet Oncol 2005; 6: 93-102.
Main BE, Calman KC, Ferguson MM, Kaye SB, Mac Far lane TW, Mairs RJ et al. The effect of cytotoxic therapy on saliva and oral flora. Oral Surg Oral Med Oral Pathol 1984; 58:545-8.
Sonis S, and Clark J. Prevention and management of oral mucositis induced by antineoplastic therapy, Oncology (Williston Park) 1991; 5:11-8.
Peterson DE. Research advances in oral mucositis. CurrOpinOncol 1999; 11: 261-66.
Diana S Early. Gastrointestinal complication of chemotherapy, Cancer chemotherapy source book, Michel C Perrie 2001; 3:427-31.
Gibson RJ and Stringer AM. Chemotherapy-induced diarrhoea, Current Opinion Support Palliative Care 2009; 3:31-5.
Joaquin J Jimenez, Hui-Sheng Huang and Adel A Yunis. Treatment with ImuVert/JV-Acetyl cysteine Protects Rats from Cyclophosphamide / Cytarabine-Induced Alopecia. Cancer Invest 1992; 10:271-6.
Jimenez JJ, Sawaya ME, and Yunis AA. Interleukin 1 protects hair follicles from cytarabine (ARA-C)-induced toxicity in vivo and in vitro. FASEB J 1992; 6:911-3.
David R. Macdonald; Neurotoxicity of chemotherapeutic agents, The Chemotherapy source book, Michael C Perry. 2nd edition 1996:752-54.
KlaasHoekman, Wim J F, van der vijgh and Jan B Vermorkan: Clinical and Preclinical Modulation of Chemotherapy induced toxicity in patients with Cancer. Drugs 1999; 57:133-5.
Asna N, Lewy H, Ashkenazi IE et al. Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity. Life Sci 2005; 76:1825-34.
Bukowski RM. The need for cytoprotection. Eur J Cancer 1996; 32A Suppl4:S2-4.
Janet M Tepton, Rolland T Steel. Acute reaction and short-term side effects of cancer chemotherapy, Handbook of cancer chemotherapy; 5th edition: 555-7.
Reilly JJ, Neifield JP, Rosenberg SA. Clinical course and management of accidental Adriaycin extravasations. Cancer 1977; 40:2053-6.
Harwitz.N. Predisposing factors in adverse reactions to drugs. Br Med J 1969; 1:536-9.
Rolland T Skeel. Handbook of Cancer Therapy, Lippincott Williams and Wilkins 5th edition: 630-2.
Shibata H. Treatment for the electrolytic disorders in cancer patients. Gan to Kagaku Ryoho 2008; 35:2330-3.
Bohannon Costa. Hepatotoxicity following VCR therapy. Cancer 1984; 54:2006-8.
Paul D King and Michael C Perry. Hepatotoxicity of chemotherapeutic agents, The Chemotherapy source book, Michael C Perry, 1996; 2nd Edition:710.
Paterson WB, Reams GP. Renal toxicities of Chemotherapy, SeminOncol 1992; 19:521-8.
Santini V. Amifostine: chemotherapeutic and radiotherapeutic protective effects. Expert OpinPharmacother 2001; 2: 479-89.
Stillwell TJ, Benson RC. Cyclophosphamide induced haemorrhagic cystitis. Cancer 1988; 61:451-7.
Weiss R B. Nephrotoxicity, Principles and Practise of Oncology, Lippincott Williams and Wilkins; 6thedition : 2968-70.Weiss R B. Nephrotoxicity, Principles and Practise of Oncology, Lippincott Williams and Wilkins; 6thedition : 2968-70.
Kreisman H, Wolkove N. Pulmonary toxicity of antineoplastic therapy. SeminOncol 1992; 19:508-20.
Keizer HG, Pinedo HM, Schuurhuis GJ and Joenje H. Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. PharmacolTher 1990; 47:219-31. 41. Michael C S Ewer and Robert S Benjamin. Cardiotoxicity of chemotherapeutic drugs, The Chemotherapy source book, 2ndedition , Michael C Perry; 1996: 651-9.
Donald C Boll and John. W Yarbro.Vascular toxicity, the chemotherapy source book, 2nd edition, Michael C Perry, 1996:767-75.
Hardy D, Liu CC, Cormier JN, Xia R, Du XL. Cardiac toxicity in association with chemotherapy and radiation therapy in a large cohort of older patients with nonsmall-cell lung cancer. Ann Oncol 2010; 21:1825-33.
Russo A, Mitchell JB. Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation. Cancer Treat Rep 1985; 69: 1293-6.
Auletta JJ, Shurin S. Improved haematopoiesis using amifostine in secondary myelodysplasia. J Paediatric Hematol Oncology 1999; 21:531-4.
Sessions J. Chronic Myeloid Leukaemia in 2007. Am J health Sys Pharm 2007; 64:S4-S9.
Coppell R Bohee. Cutaneous reaction to chemotherapeutic agents. American Journal of Medical Sciences 2001; 321:327-35.
Feldman DR, Bosl GJ, Sheinfeld J and Motzer RJ. Medical treatment of advanced testicular cancer, JAMA 2008; 299:672-84.
Wolf JK, Dwayne JA. Gene therapy for ovarian cancer. Int J Oncol 2002; 21:461-8.
Linda J Burns. Ocular side effects of chemotherapy, The Chemotherapy source book, 2nd edition, Michael C Perry; 1996:638.
M N G Dukes. Meylers side effects of drugs, AnEncyclopaedia of Adverse reactions and Interactions, 11th Edition; 1988: 952.
