Microwave Assisted Synthesis and Antiinflammatory Activity of Substituted Pyrazole Derivatives
Keywords:
pyrazole; pyrazolones; anti-inflammatory activity; MORE; microwave chemistryAbstract
Microwave assisted Organic Reaction Enhancement (MORE) has emerged as a new ‘lead’ in organic synthesis. The technique offers simple, clean, fast, efficient, and economic and environment friendly method for the synthesis of a large number of organic molecules. During our studies, the conventional synthesis of a series of some new substituted 3, 5 dimethyl pyrazole (4a-c), 3-methyl pyrazol-5-one derivatives (5ac), 3-Methyl- 1- (substituted phenyl) pyrazol-5-ones (7a-b) and 2, 3-dimethyl- 1- (substituted phenyl) pyrazol-5-one (8a-b) required time (12-16 h) and the yield were often poor (36.9-48.6%). The synthesis of the title compounds using microwave irradiation with an objective to reduce reaction time and increases the yield, all the reaction could be completed in very short duration (4-7 min) with considerable increase in the yields (54-81%) by Using microwave irradiation,. The newly synthesized compounds were evaluated for anti-inflammatory activity.
How to cite this article: Rastogi S, Srivastava N. Microwave Assisted Synthesis and Anti-inflammatory Activity of Substituted Pyrazole Derivatives. Int J Adv Res Med Chem 2019; 1(1): 8-13.
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