Gastroretentive Drug Delivery System

Authors

  • Mr. Wasim Fayaz
  • Pankaj Chasta Assistant Professor, Faculty of Pharmaceutical Sciences, Mewar University, Chittorgarh, Rajasthan, India-312901.
  • Tawseef Hassan Sheikh Faculty of Pharmaceutical Sciences, Mewar University, Chittorgarh, Rajasthan, India-312901.
  • Muddasir Ahmad Rather Faculty of Pharmaceutical Sciences, Mewar University, Chittorgarh, Rajasthan, India-312901.
  • Aqib Hussain Kumar Faculty of Pharmaceutical Sciences, Mewar University, Chittorgarh, Rajasthan, India-312901.
  • Aadil Mustafa Faculty of Pharmaceutical Sciences, Mewar University, Chittorgarh, Rajasthan, India-312901.

Abstract

Gastroretentive dosage form (GRDF) has played an important role in the past few periods in improving the limitation of most predictable and oral controlled release drug delivery system related to fast gastricemptying time. GRDF system can be defined as a system which remains in the stomach for an adequate time interval against all the physiological barriers, and releases active moiety in a well-ordered manner. This paper gives an overview of the parameters affecting gastric emptying as well as on the main thoughts used to design pharmaceutical dosage forms with prolonged gastric residence times. In particular, bioadhesive, size-increasing, and floating drug delivery systems are presented, and their major advantages and limitations are discussed. Both single and multiple-unit dosage forms with dual working arrangements are reviewed. Dual-working classifications are more efficient than the traditional systems.

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Published

2018-10-27

How to Cite

Fayaz, M. W., Chasta, P., Sheikh, T. H., Rather, M. A., Kumar, A. H., & Mustafa, A. (2018). Gastroretentive Drug Delivery System. Journal of Drug Discovery and Development ( ISSN:2581-6861), 2(1), 11-17. Retrieved from http://www.medicaljournalshouse.com/index.php/JDrug-Discovery-Development/article/view/59

Issue

Vol. 2 No. 1 (2018): Journal of Drug Discovery and Development

Section

Research Article

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