An Overview of Drug-Induced Peripheral Neuropathy: Mechanisms and Management
Abstract
Drug-induced peripheral neuropathy (DIPN) is a prevalent and often debilitating condition resulting from the neurotoxic effects of various medications, particularly chemotherapeutic agents, antiretroviral drugs, and certain antibiotics. This overview aims to elucidate the mechanisms, clinical manifestations, and management strategies of DIPN. The underlying mechanisms of DIPN include mitochondrial toxicity, disruption of axonal transport, oxidative stress, direct neurotoxic effects, and immune-mediated pathways. These mechanisms contribute to the diverse clinical presentations of DIPN, which can manifest as sensory, motor, autonomic, or mixed neuropathies, each with distinct symptoms
and functional impairments. Early recognition and comprehensive assessment of DIPN are crucial for effective management. This involves regular monitoring for neuropathic symptoms, thorough neurological examinations, and appropriate diagnostic testing. Management strategies focus on modifying causative medications through dose adjustments or substitutions, providing symptomatic treatment with analgesics, anticonvulsants, and topical agents, and employing neuroprotective interventions such as antioxidants and neurotrophic factors. Physical therapy and patient
education play vital roles in maintaining functionality and enhancing quality of life.
How to cite this article:
Gosh A, Diwakar P. An Overview of Drug-Induced
Peripheral Neuropathy: Mechanisms and
Management. J Durg Dis Dev 2024; 8(1): 6-10.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Journal of Drug Discovery and Development ( ISSN:2581-6861)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
We, the undersigned, give an undertaking to the following effect with regard to our article entitled
“_______________________________________________________________________________________________________________________________________________________________________________
________________________________________________________________________________” submitted for publication in (Journal title)________________________________________________ _______________________________________________________Vol.________, Year _________:-
1. The article mentioned above has not been published or submitted to or accepted for publication in any form, in any other journal.
2. We also vouchsafe that the authorship of this article will not be contested by anyone whose name(s) is/are not listed by us here.
3. I/We declare that I/We contributed significantly towards the research study i.e., (a) conception, design and/or analysis and interpretation of data and to (b) drafting the article or revising it critically for important intellectual content and on (c) final approval of the version to be published.
4. I/We hereby acknowledge ADRs conflict of interest policy requirement to scrupulously avoid direct and indirect conflicts of interest and, accordingly, hereby agree to promptly inform the editor or editor's designee of any business, commercial, or other proprietary support, relationships, or interests that I/We may have which relate directly or indirectly to the subject of the work.
5. I/We also agree to the authorship of the article in the following sequence:-
Authors' Names (in sequence) Signature of Authors
1. _____________________________________ _____________________________________
2. _____________________________________ _____________________________________
3. _____________________________________ _____________________________________
4. _____________________________________ _____________________________________
5. _____________________________________ _____________________________________
6. _____________________________________ _____________________________________
7. _____________________________________ _____________________________________
8. _____________________________________ _____________________________________
Important
(I). All the authors are required to sign independently in this form in the sequence given above. In case an author has left the institution/ country and whose whereabouts are not known, the senior author may sign on his/ her behalf taking the responsibility.
(ii). No addition/ deletion/ or any change in the sequence of the authorship will be permissible at a later stage, without valid reasons and permission of the Editor.
(iii). If the authorship is contested at any stage, the article will be either returned or will not be
processed for publication till the issue is solved.
