Effect of Fumaria Capreolata Total Alkaloid Extract on Acetic Acid-induced Ulcerative Colitis in NMRI Mice

Authors

  • Noureddine Bribi Université de Bejaia, Laboratoire de Biotechnologie Végétale et Ethnobotanique, Faculté des sciences de la Nature et de la Vie, Bejaia, Algeria
  • Mohamed Sofiane Merakeb Université de Bejaia, Laboratoire de Biotechnologie Végétale et Ethnobotanique, Faculté des sciences de la Nature et de la Vie, Bejaia 06000, Algeria
  • Safia Afenai Université de Bejaia, Laboratoire de Biotechnologie Végétale et Ethnobotanique, Faculté des sciences de la Nature et de la Vie, Bejaia 06000, Algeria

Keywords:

Acetic-acid, Alkaloids, Fumaria capreolata, Anti inflammatory, Colitis

Abstract

Background: Fumaria capreolata has been used in North African traditional medicine for its gastrointestinal benefits and anti-inflammatory effects.
Objective: This study explores the intestinal anti-inflammatory effects of total alkaloids extracted from the aerial parts of Fumaria capreolata (AFC) against acetic acid-induced experimental colitis in mice.
Methods: Intestinal anti-inflammatory effects of AFC (6.25, 12.5, and 25 mg/kg) were evaluated using the acetic acid-induced ulcerative colitis model in male NMRI mice. Colonic damage was assessed through colitis parameters and histological analysis of the colon.
Results: This study demonstrated that pre-treatment with AFC alleviates intestinal damage and clinical symptoms of ulcerative colitis. Histological analysis revealed that AFC helped preserve the integrity of the intestinal barrier. This finding was further supported by the colonic weight/length (W/L) ratio calculations.
Conclusion: AFC demonstrates potential as a promising candidate for preventing inflammatory diseases, such as colitis.

How to cite this article:
Bribi N, Merakeb M S, Afenai S. Effect of Fumaria
Capreolata Total Alkaloid Extract on Acetic Acid-
induced Ulcerative Colitis in NMRI Mice. Int J Adv
Res MicroBiol Immunol. 2025;8(1):1-6.

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Published

2025-04-24

Issue

Vol. 8 No. 1 (2025): International Journal of Advanced Research in Microbiology and Immunology

Section

Research Article

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