Platelet Indices: Indicators of Diabetes

Authors

  • Shefali Mittal School of Medical Health Sciences and Research Institute, Sharda Medical College, Greater Noida
  • Suparna Dubey School of Medical Health Sciences and Research Institute, Sharda Medical College, Greater Noida
  • J L Goyal School of Medical Health Sciences and Research Institute, Sharda Medical College, Greater Noida
  • Jyoti Mishra School of Medical Health Sciences and Research Institute, Sharda Medical College, Greater Noida
  • Charu

Keywords:

WHO- World Health Organization, DM- Diabetes Mellitus, RBC- Red Blood Cells, MPV- Mean Platelet Volume, PDW- Platelet Distribution Width, ADP- Adinosine diphosphate, FPG- Fasting Plasma Glucose, T2DM- Type 2 Diabetes Mellitus, IGT- Impaired Glucose Tolerance, PLT- Platelet, PLCR- Platelet-Large Cell Ratio, CBC- Complete Blood Count, MPI- Mean Platelet Indices, PCT- Plateletcrit, PVI- Platelet Volume Indices, PGE- Prostaglandin E, PGI- Prostaglandin I, NO- Nitric Oxide, GP- Glycoprotein

Abstract

  • Aim and Objectives: The aim of this study is to study role of platelet
    indices in with and without diabetes. The objectives included assessing
    platelet count, mean platelet volume (MPV), platelet distribution
    width (PDW), and platelet large cell ratio (P-LCR) within these patient
    categories and to comparing platelet indices among healthy controls
    and diabetic patients.
    Materals and Methods: This prospective case-control study was
    conducted at Departments of Pathology and Ophthalmology, School
    of Medical Sciences & Research, Sharda Hospital, Greater Noida. Over
    one and a half years, 100cases were enrolled, divided into 2 groups:
    controls and Diabetics .The patients coming to ophthalmology opd for
    retina checkup, their blood sample was taken. As same vial is used for
    both estimation of platelet indices and HBA1C, both blood investigations
    were noted. Inclusion criteria were adult patients with type 2 diabetes.
    Exclusion criterion was anemia, certain eye conditions, uncontrolled
    hypertension, cardiovascular issues, renal failure, anti-platelet drug
    usage, malignancy, and type 1 diabetes were made.
    Results: The results revealed significant variations among the groups.
    In controls, the majority (90%) had MPV below 12, whereas in diabetic
    patients most (58%) had MPV ranging from 12 to 15. PDW showed
    similar trends, with 96% of controls having PDW below 17, while 96%
    of diabetic patients was having as >20 . PLCR percentages ranged
    within normal limits for controls but shifted towards higher values in
    diabetic group. Platelet counts were consistent between control and
    diabetic without Diabetes groups, averaging around 252,000 x10^3/
    cumm, while diabetic patients had a slightly lower average count of
    approximately 242,000 x10^3/cumm .
    Conclusion: Thus we conclude that platelet indices are cost effective, easily
    available, more reliant and more compliant tools which can indicate the
    progression diabetes. MPV, PDW,PLCR and PLATELET COUNT, can play an
    important role in Early detection , better diagnosis and prognosis of Diabetes.
    Keywords: Mean Platelet Count, Platelet Distribution Width , Platelet
    Large Cell Ratio, Diabete.
  • How to cite this article:
    Mittal S, Dubey S, Goyal J L, Mishra J, Charu.
    Platelet Indices: Indicators of Diabetes. Rec Adv
    Path Lab Med. 2025;11(1&2):7-10.
  • DOI: https://doi.org/10.24321/2454.8642.202501

References

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Published

2025-04-29

Issue

Vol. 11 No. 1&2 (2025): Recent Advances in Pathology & Laboratory Medicine

Section

Research Article

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