Concurrent Presence of Haemoglobin S and Hemoglobin D in Pregnancy: A Case Report

Authors

  • Kavitha Yevoor Department of pathology, Karnataka Institute of medical Sciences, Vidyanagar, Hubli, Karnataka, India.
  • Arathi S Department of pathology, Karnataka Institute of medical Sciences, Vidyanagar, Hubli, Karnataka, India.
  • Choukimath S M
  • Ankita A Muktawar

Keywords:

Double heterozygous, HbSD, Pregnancy

Abstract

Introduction: Haemoglobinopathy is the clinical condition that arises from genetically abnormal structure or synthesis of the haemoglobin molecule. Among the inherited disorders of the blood,   haemoglobinopathies and thalassemia constitute a major bulk of non- communicable genetic diseases in India. Heterozygous Haemoglobin   Sickle Cell Disease (HbSC) is the second most frequent Haemoglobinopathy Behind Sickle Cell Anaemia (SCA). Compound heterozygous HbSD-Punjab is an uncommon haemoglobinopathy encountered in Indians. Hereby   we have presented a case with clinical and laboratory findings of HbSD- Punjab accidentally diagnosed when a primigravida female came to   the hospital with severe anaemia. Case Report: A 34-year-old primigravida came to the hospital with complaints of breathlessness. On a complete haemogram with a peripheral smear (CH with PS), it was revealed that haemoglobin was 7.6% and RBCs were normocytic normochromic with many nucleated RBCs (nRBCs). High-Performance Liquid Chromatography (HPLC) showed double heterozygosity for HbS and HbD. Conclusion: Double heterozygosity for HbSD is a rare disorder. Genetic Counselling is recommended. How to cite this article:
Yevoor K, Arathi S, Choukimath S M, Muktawar
A A . Concurrent Presence of Haemoglobin S
and Hemoglobin D in Pregnancy: A Case Report
.Rec Adv Path Lab Med. 2024;10(1&2):4-6. DOI: https://doi.org/10.24321/2454.8642.202404

References

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Published

2025-04-07

Issue

Vol. 10 No. 1&2 (2024): Recent Advances in Pathology and Laboratory Medicine (RAPL)

Section

Case Report

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Copyright (c) 2024 Recent Advances in Pathology and Laboratory Medicine ( ISSN: 2454-8642 )

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